Silylation Derivatization Reagent, MTBSTFA w/1% TBDMCS (N-Methyl-N[tert-Butyldimethylsilyl Trifluoroacetamide] w/1% tert-Butyldimethylchlorosilane), 10×1 g Vials, 10-pk.

Silylation is the most widely used derivatization procedure for sample analysis by GC. In silylation, an active hydrogen is replaced by an alkylsilyl group such as trimethylsilyl (TMS) or tert-butyldimethylsilyl (tert-BDMS). Silyl derivatives are more volatile, less polar, and more thermally stable. As a result, GC separation is improved, and detection is enhanced.

Both TMS and tert-BDMS reagents are suitable for a wide variety of compounds and can be used for many GC applications. (Note that silylation reagents are generally moisture-sensitive and must be sealed to prevent deactivation.)

Features & Benefits

• Replace active hydrogen, reducing polarity and making the compounds more volatile.
• Increase stability of derivatives.